Nika Avia

Niosomal mefloquine and cisplatin in breastcancer: comparative effects on apoptosisand angiogenesis via in vitro and in silicoanalysis

| Published Research Articles

🔬 Introduction Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Among its subtypes, Triple-Negative Breast Cancer (TNBC) is particularly aggressive due to the absence of estrogen, progesterone, and HER2 receptors, making targeted therapy challenging.Apoptosis resistance and enhanced angiogenesis are two major hallmarks of TNBC progression. Targeting both pathways simultaneously […]

Niosomal mefloquine and cisplatin in breastcancer: comparative effects on apoptosisand angiogenesis via in vitro and in silicoanalysis Read Post »

Enhancing Antitumor Efficacy of MUC1 mRNA Nano-Vaccine byCTLA-4 siRNA-Mediated Immune Checkpoint Modulation inTriple Negative Breast Cancer Mice Model

| Published Research Articles

🔬 Introduction Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant subtypes of breast cancer. Unlike other forms, TNBC lacks estrogen, progesterone, and HER2 receptors, limiting targeted therapy options and increasing reliance on chemotherapy.Recent advances in RNA-based cancer vaccines and immunotherapy have opened new therapeutic pathways. However, most mRNA vaccines focus only

Enhancing Antitumor Efficacy of MUC1 mRNA Nano-Vaccine byCTLA-4 siRNA-Mediated Immune Checkpoint Modulation inTriple Negative Breast Cancer Mice Model Read Post »

Topical Administration of Mucoadhesive Liposomes−Epoetin‑β forTargeting the Ocular Posterior Segment

| Published Research Articles

🔬 Introduction Delivering therapeutic agents to the posterior segment of the eye remains one of the greatest challenges in ophthalmology. Diseases such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy primarily affect the retina and optic nerve, often leading to irreversible vision loss. Conventional delivery methods—including intravitreal injections and systemic administration—are either invasive or

Topical Administration of Mucoadhesive Liposomes−Epoetin‑β forTargeting the Ocular Posterior Segment Read Post »

Exosome Enveloped by Nano Lipid Particle a New Model forSignal Transducer and Activator of Transcription 3 SilencerRibonucleic Acid Delivery System to a Glioblastoma Mice Model

| Published Research Articles

📖 Introduction Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor in adults. Despite surgery, radiotherapy, and chemotherapy, the median survival remains only 12–15 months. One of the major therapeutic challenges is the blood–brain barrier (BBB), which restricts drug delivery to brain tissue.Signal Transducer and Activator of Transcription 3 (STAT3) is a key

Exosome Enveloped by Nano Lipid Particle a New Model forSignal Transducer and Activator of Transcription 3 SilencerRibonucleic Acid Delivery System to a Glioblastoma Mice Model Read Post »

Microfluidic techniques in the development of PLGA nanoparticles: a tri-combination therapy for paraquat-induced cytotoxicity

| Published Research Articles

Introduction Paraquat (PQ) is a widely used herbicide that is highly toxic to humans, particularly causing acute lung injury and pulmonary fibrosis. Current treatments are limited and largely ineffective, with no specific antidote available. To address this, researchers explored the use of poly(lactic‑co‑glycolic acid) (PLGA) nanoparticles as carriers for three therapeutic agents—Pirfenidone (PFD), Quercetin (Que),

Microfluidic techniques in the development of PLGA nanoparticles: a tri-combination therapy for paraquat-induced cytotoxicity Read Post »

Stabilization of cationic liposomes using hyaluronic acid-modified gold nanoparticles by post-microfluidics conjugation approach for drug delivery applications

| Published Research Articles

Introduction A major challenge in liposomal drug delivery is the poor stability of cationic liposomes in physiological conditions. To address this, researchers developed a hybrid system combining hyaluronic acid-modified gold nanoparticles (HA-AuNPs) with cationic liposomes. This innovative surface engineering strategy improves liposome stability while preserving their drug delivery potential — especially for cancer therapies. 💡

Stabilization of cationic liposomes using hyaluronic acid-modified gold nanoparticles by post-microfluidics conjugation approach for drug delivery applications Read Post »

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