Enhancing Antitumor Efficacy of MUC1 mRNA Nano-Vaccine byCTLA-4 siRNA-Mediated Immune Checkpoint Modulation inTriple Negative Breast Cancer Mice Model
🔬 Introduction Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant subtypes of breast cancer. Unlike other forms, TNBC lacks estrogen, progesterone, and HER2 receptors, limiting targeted therapy options and increasing reliance on chemotherapy.Recent advances in RNA-based cancer vaccines and immunotherapy have opened new therapeutic pathways. However, most mRNA vaccines focus only […]
